VPRIV PREPARATION

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VPRIV PREPARATION

Supplies Needed

VPRIV is a lyophilized powder that requires reconstitution and dilution, using sterile technique,
prior to intravenous (IV) infusion.1 The following supplies will help with the preparation and
administration of VPRIV:

IV bag

IV Apparatus

  • IV infusion pump
  • IV start kit
  • IV infusion tubing
  • In-line low protein-binding 0.2 or 0.22 μm filter
Syringe

Equipment

  • Syringes and ≤20 gauge needles
  • Angiocatheter
  • If initiating treatment, appropriate medical monitoring and support measures, including access to cardiopulmonary resuscitation equipment should be available
  • Anaphylaxis kit
  • Antihistamines and/or corticosteroids
    as pre-treatment as needed or per facility infusion protocol
Liquid drop

Solutions

  • Sterile Water for Injection, USP
  • 100 mL of 0.9% Sodium Chloride Injection, USP
VPRIV HCP Brochure

Storage & Handling

Powder being poured into glass of liquid

VPRIV is a sterile, white to off-white, lyophilized powder supplied in
individually packaged single-dose glass vials, requiring reconstitution
and dilution prior to use1

Thermometer showing 36 degrees fahrenheit to 46 degrees fahrenheit

VPRIV should be stored refrigerated at 36°F to 46°F (2°C to 8°C) in the
original carton away from light. Do not freeze VPRIV1

Clock with a warning exclamation mark

Check the expiration date on the vial and DO NOT use VPRIV after the
expiration date1

VPRIV HCP Brochure

Reconstitution & Dilution

VPRIV is a lyophilized powder that requires reconstitution and dilution, using sterile technique, prior to intravenous infusion.1 VPRIV should be prepared as follows1:

Step 1 – Weighing scale
1

Determine the number of vials to be reconstituted based on the individual patient’s weight and the prescribed
dose. See Dosing Calculation for VPRIV dosing guidelines.

Step 2 – Injecting water into a vial
2

Inject 4.3 mL of Sterile Water for Injection, USP, into a vial containing VPRIV powder. Mix gently,
do not shake. The reconstituted VPRIV solution will have a 100 U/mL concentration (400 U of
VPRIV in 4 mL of solution). If more vials are needed, repeat the above steps.

Step 3 – Magnifying glass over a drop of liquid
3

Visually inspect the solution in the vials. It should be clear to slightly opalescent and colorless.
Do not use if the solution is discolored or if foreign particulate matter is present.*

Step 4 – Syringe withdrawing drug from vial
4

Use a single syringe to withdraw the calculated dosage of drug from the appropriate number of
prepared vials. See Dosing Calculation for VPRIV Dosing Calculation. Using a separate syringe, withdraw
air from a bag of 100 mL of 0.9% Sodium Chloride Injection suitable for IV administration. Inject the
calculated dosage of prepared VPRIV directly into the 0.9% Sodium Chloride Injection to dilute.

Step 5 – IV bag being mixed
5

Mix gently, do not shake. Slight flocculation (white irregularly shaped particles) may occasionally
occur. A diluted solution with slight flocculation is acceptable for administration.

Step 6 – IV bag with 24 hours marked on
6

Place medication label on the IV bag according to site/organization policy. Use immediately. If immediate
use is not possible, the diluted VPRIV solution may be stored for up to 24 hours at 36°F to 46°F (2°C to
8°C). Do not freeze, and protect from light. Complete the infusion within 24 hours of reconstitution.

*Contact Medical Information at 1-866-888-0660, option 2 or email medinfous@takeda.com for all US inquiries if the solution is discolored or if foreign particulate matter is present.

VPRIV Dosing Calculator
VPRIV Dosing Calculator
VPRIV Administration
VPRIV Administration